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It was introduced as a medication in France in 1957. [16] [30] It is on the World Health Organization's List of Essential Medicines. [31] It is available as a generic medication. [16] In 2022, it was the second most commonly prescribed medication in the United States, with more than 86 million prescriptions.
Trazodone was approved for medical use in the United States in 1981. [20] It is available as a generic medication. [20] In 2022, it was the eighteenth most commonly prescribed medication in the United States, with more than 27 million prescriptions. [25] [26]
Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization. [7] [8] It is taken by mouth. [7] Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). [9]
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Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. [11] [12] Its effects may take up to four weeks but can also manifest as early as one to two weeks.
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