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It was introduced as a medication in France in 1957. [16] [30] It is on the World Health Organization's List of Essential Medicines. [31] It is available as a generic medication. [16] In 2022, it was the second most commonly prescribed medication in the United States, with more than 86 million prescriptions.
Trazodone, sold under many brand names, [ 1 ] is an antidepressant medication, [ 20 ] used to treat major depressive disorder, anxiety disorders, and insomnia. [ 20 ] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. [ 21 ][ 22 ] The medication is taken orally.
Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization. [7] [8] It is taken by mouth. [7] Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). [9]
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Mirtazapine is a tetracyclic piperazinoazepine; mianserin was developed by the same team of organic chemists and mirtazapine differs from it via addition of a nitrogen atom in one of the rings. [115]: 429 [116][117] It is a racemic mixture of enantiomers. The (S)- (+)-enantiomer is known as esmirtazapine.
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