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Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
Neurology. Early-onset Alzheimer's disease ( EOAD ), also called younger-onset Alzheimer's disease ( YOAD ), [ 1] is Alzheimer's disease diagnosed before the age of 65. [ 2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are ...
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal ...
Dementia is currently the seventh leading cause of death worldwide and has 10 million new cases reported every year (approximately one every three seconds). [2] There is no known cure for dementia. Acetylcholinesterase inhibitors such as donepezil are often used and may be beneficial in mild to moderate disorder, but the overall benefit may be ...
A neurodegenerative diseaseis caused by the progressive loss of neurons, in the process known as neurodegeneration. [2][3]Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system ...
Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [ 24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular membranes.
Medical condition Dementia with Lewy bodies Other names Diffuse Lewy body disease, dementia due to Lewy body disease Microscopic image of a Lewy body (arrowhead) in a neuron of the substantia nigra ; scale bar=20 microns (0.02 mm) Specialty Neurology, psychiatry Symptoms Dementia, abnormal behavior during REM sleep, fluctuations in alertness, visual hallucinations, parkinsonism Usual onset ...
This is a list of major and frequently observed neurological disorders (e.g., Alzheimer's disease), symptoms (e.g., back pain), signs (e.g., aphasia) and syndromes (e.g., Aicardi syndrome). There is disagreement over the definitions and criteria used to delineate various disorders and whether some of these conditions should be classified as ...
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