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A study found that ritonavir, a strong CYP3A4 and CYP2D6 inhibitor and moderate CYP1A2 inducer, increased trazodone peak levels by 1.4-fold, trazodone area-under-the-curve levels by 2.4-fold, and decreased trazodone clearance by 50%. [17] [12] This was associated with adverse effects such as nausea, hypotension, and syncope. [17]
Official website. Launched. September 2022. Temu (/ ˈtiːmuː / ⓘ TEE-moo) is an online marketplace operated by the Chinese e-commerce company PDD Holdings. [8][9] It offers heavily discounted consumer goods [10] mostly shipped to consumers directly from China. [11][12] Temu's business model has allowed it to become popular among consumers ...
Clearance (pharmacology) In pharmacology, clearance ( ) is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
The hybrid is said to give approximately 75% greater efficiency, the FWD version has EPA ratings of 30 mpg and 28 highway, with combined 29 mpg. The AWD version EPA ratings 28 city and 26 highway, combined 27 mpg -U.S. in city traffic, and has demonstrated it can travel 400–500 miles (644–805 km) on a single 15.0-U.S.-gallon (57 L; 12.5 imp ...
Canada's total population enumerated by the 2006 census was 31,612,897. [49] This count was lower than the official 1 July 2006 population estimate of 32,623,490 people. [49] Ninety per cent of the population growth between 2001 and 2006 was concentrated in the main metropolitan areas. [50]
Cathay Pacific is the flag carrier of Hong Kong with its head office and main hub located at Hong Kong International Airport.The airline's operations and its subsidiaries have scheduled passenger and cargo services to more than 190 [5] [6] destinations and more than 60 countries worldwide including codeshares and joint ventures.
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